Selected article for: "clinical information and large cohort"
Author: Flores-Silva, Fernando Daniel; García-Grimshaw, Miguel; Valdés-Ferrer, Sergio Iván; Vigueras-Hernández, Alma Poema; Domínguez-Moreno, Rogelio; Tristán-Samaniego, Dioselina Panamá; Michel-Chávez, Anaclara; González-Duarte, Alejandra; Vega-Boada, Felipe A.; Reyes-Melo, Isael; Jiménez-Ruiz, Amado; Chávez-Martínez, Oswaldo Alan; Rebolledo-García, Daniel; Marché-Fernández, Osvaldo Alexis; Sánchez-Torres, Samantha; García-Ramos, Guillermo; Cantú-Brito, Carlos; Chiquete, Erwin
Title: Neurologic manifestations in hospitalized patients with COVID-19 in Mexico City
  • Cord-id: b3mb63qa
  • Document date: 2021_4_8
    • ID: b3mb63qa
    Snippet: BACKGROUND: The coronavirus disease 2019 (COVID-19) is a systemic entity that frequently implies neurologic features at presentation and complications during the disease course. We aimed to describe the characteristics and predictors for developing in-hospital neurologic manifestations in a large cohort of hospitalized patients with COVID-19 in Mexico City. METHODS: We analyzed records from consecutive adult patients hospitalized from March 15 to June 30, 2020, with moderate to severe COVID-19 c
    Document: BACKGROUND: The coronavirus disease 2019 (COVID-19) is a systemic entity that frequently implies neurologic features at presentation and complications during the disease course. We aimed to describe the characteristics and predictors for developing in-hospital neurologic manifestations in a large cohort of hospitalized patients with COVID-19 in Mexico City. METHODS: We analyzed records from consecutive adult patients hospitalized from March 15 to June 30, 2020, with moderate to severe COVID-19 confirmed by reverse transcription real-time polymerase chain reaction (rtRT-PCR) for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Neurologic syndromes were actively searched by a standardized structured questionnaire and physical examination, confirmed by neuroimaging, neurophysiology of laboratory analyses, as applicable. RESULTS: We studied 1,072 cases (65% men, mean age 53.2±13 years), 71 patients had pre-existing neurologic diseases (diabetic neuropathy: 17, epilepsy: 15, history of ischemic stroke: eight, migraine: six, multiple sclerosis: one, Parkinson disease: one), and 163 (15.2%) developed a new neurologic complication. Headache (41.7%), myalgia (38.5%), dysgeusia (8%), and anosmia (7%) were the most common neurologic symptoms at hospital presentation. Delirium (13.1%), objective limb weakness (5.1%), and delayed recovery of mental status after sedation withdrawal (2.5%), were the most common new neurologic syndromes. Age, headache at presentation, preexisting neurologic disease, invasive mechanical ventilation, and neutrophil/lymphocyte ratio ≥9 were independent predictors of new in-hospital neurologic complications. CONCLUSIONS: Even after excluding initial clinical features and pre-existing comorbidities, new neurologic complications in hospitalized patients with COVID-19 are frequent and can be predicted from clinical information at hospital admission.

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