Selected article for: "gag bind and HS bind"
Author: Courtney Mycroft-West; Dunhao Su; Stefano Elli; Scott Guimond; Gavin Miller; Jeremy Turnbull; Edwin Yates; Marco Guerrini; David Fernig; Marcelo Lima; Mark Skidmore
Title: The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding
  • Document date: 2020_3_2
    • ID: 0d77ojnb_2
    Snippet: Traditional drug development processes are slow and ineffective against emerging public health threats such as the current SARS-CoV-2 coronavirus outbreak which makes the repurposing of existing drugs a timely and attractive alternative. Heparin, a well-tolerated anticoagulant pharmaceutical, has been used safely in medicine for over 80 years and alongside its anticoagulant activities, its ability to prevent viral infection, including coronavirid.....
    Document: Traditional drug development processes are slow and ineffective against emerging public health threats such as the current SARS-CoV-2 coronavirus outbreak which makes the repurposing of existing drugs a timely and attractive alternative. Heparin, a well-tolerated anticoagulant pharmaceutical, has been used safely in medicine for over 80 years and alongside its anticoagulant activities, its ability to prevent viral infection, including coronaviridae, has been described 1 . Furthermore, the closely related glycosaminoglycan (GAG) member, heparan sulfate (HS), is known to bind CoV surface proteins and to be used by coronavirus for its attachment to target cells 9 .

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