Author: Courtney Mycroft-West; Dunhao Su; Stefano Elli; Scott Guimond; Gavin Miller; Jeremy Turnbull; Edwin Yates; Marco Guerrini; David Fernig; Marcelo Lima; Mark Skidmore
Title: The 2019 coronavirus (SARS-CoV-2) surface protein (Spike) S1 Receptor Binding Domain undergoes conformational change upon heparin binding Document date: 2020_3_2
ID: 0d77ojnb_25
Snippet: Glycosaminoglycans are ubiquitously present on almost all mammalian cells and this class of carbohydrates are central to the strategy employed by coronaviridae to attach to host cells. Heparin has previously been shown to inhibit SARS-associated coronavirus strain HSR1 cell invasion 2, 18 and this, in concert with the data presented within this study, supports the utilisation of glycosaminoglycan-derived pharmaceuticals against SARS-associated co.....
Document: Glycosaminoglycans are ubiquitously present on almost all mammalian cells and this class of carbohydrates are central to the strategy employed by coronaviridae to attach to host cells. Heparin has previously been shown to inhibit SARS-associated coronavirus strain HSR1 cell invasion 2, 18 and this, in concert with the data presented within this study, supports the utilisation of glycosaminoglycan-derived pharmaceuticals against SARS-associated coronavirus. Furthermore, this study strongly supports the repurposing of heparin and its derivatives as antiviral agents, providing a rapid countermeasure against the current SARS-CoV-2 outbreak.
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