Author: Shah, Muhammad Ajmal; Rasul, Azhar; Yousaf, Rimsha; Haris, Muhammad; Faheem, Hafiza Ishmal; Hamid, Ayesha; Khan, Haroon; Khan, Abdul Haleem; Aschnar, Michael; Batiha, Gaber Elâ€Saber
Title: Combination of natural antivirals and potent immune invigorators: A natural remedy to combat COVIDâ€19 Cord-id: 5epe0jgu Document date: 2021_8_15
ID: 5epe0jgu
Snippet: The flareâ€up in severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) that emerged in December 2019 in Wuhan, China, and spread expeditiously worldwide has become a health challenge globally. The rapid transmission, absence of antiâ€SARSâ€CoVâ€2 drugs, and inexistence of vaccine are further exacerbating the situation. Several drugs, including chloroquine, remdesivir, and favipiravir, are presently undergoing clinical investigation to further scrutinize their effectiveness and val
Document: The flareâ€up in severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) that emerged in December 2019 in Wuhan, China, and spread expeditiously worldwide has become a health challenge globally. The rapid transmission, absence of antiâ€SARSâ€CoVâ€2 drugs, and inexistence of vaccine are further exacerbating the situation. Several drugs, including chloroquine, remdesivir, and favipiravir, are presently undergoing clinical investigation to further scrutinize their effectiveness and validity in the management of COVIDâ€19. Natural products (NPs) in general, and plants constituents specifically, are unique sources for various effective and novel drugs. Immunostimulants, including vitamins, iron, zinc, chrysin, caffeic acid, and gallic acid, act as potent weapons against COVIDâ€19 by reinvigorating the defensive mechanisms of the immune system. Immunity boosters prevent COVIDâ€19 by stimulating the proliferation of Tâ€cells, Bâ€cells, and neutrophils, neutralizing the free radicals, inhibiting the immunosuppressive agents, and promoting cytokine production. Presently, antiviral therapy includes several lead compounds, such as baicalin, glycyrrhizin, theaflavin, and herbacetin, all of which seem to act against SARSâ€CoVâ€2 via particular targets, such as blocking virus entry, attachment to host cell receptor, inhibiting viral replication, and assembly and release.
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