Author: Ao-Xiang Guo; Jia-Jia Cui; Qian-Ying OuYang; Li He; Cheng-Xian Guo; Ji-Ye Yin
Title: The clinical characteristics and mortal causes analysis of COVID-19 death patients Document date: 2020_4_15
ID: dtlwjndn_34
Snippet: While that ACE2 was highly expressed in heart may be related with the attack of SARS-CoV-2 in heart, which may lead to the initial symptoms of palpitate and chest tightness in some patients, and the direct causes of death including circulatory failure, heart disease and cardiac arrest. ACE2 also had a high expression in adipose, which may be related with obesity. Besides, both TMPRSS2 and ACE2 had a high expression in transverse colon and small i.....
Document: While that ACE2 was highly expressed in heart may be related with the attack of SARS-CoV-2 in heart, which may lead to the initial symptoms of palpitate and chest tightness in some patients, and the direct causes of death including circulatory failure, heart disease and cardiac arrest. ACE2 also had a high expression in adipose, which may be related with obesity. Besides, both TMPRSS2 and ACE2 had a high expression in transverse colon and small intestine-terminal ileum, which may be associated with the initial symptom of diarrhea. (Figure 2) Taken these results together, TMPRSS2 or ACE2 was highly expressed in the organs with clinical characteristics of dead patients. The expression of the SARS-CoV-2 targets in these important organs such as lung, heart, liver and kidney may help to explain the clinical characteristics of death patients. However, the two targets were also highly expressed in some other organs without obvious clinical symptoms such as pancreas, thyroid, breast, prostate and thyroid. These organs may also be injured but didn't cause obvious clinical symptoms, which should also be paid attention.
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