Author: Kawasaki, Takumi; Kawai, Taro; Akira, Shizuo
Title: Recognition of nucleic acids by patternâ€recognition receptors and its relevance in autoimmunity Cord-id: 5g2ou5cu Document date: 2011_8_26
ID: 5g2ou5cu
Snippet: Summary: Host cells trigger signals for innate immune responses upon recognition of conserved structures in microbial pathogens. Nucleic acids, which are critical components for inheriting genetic information in all species including pathogens, are key structures sensed by the innate immune system. The corresponding receptors for foreign nucleic acids include members of Tollâ€like receptors, RIGâ€Iâ€like receptors, and intracellular DNA sensors. While nucleic acid recognition by these recepto
Document: Summary: Host cells trigger signals for innate immune responses upon recognition of conserved structures in microbial pathogens. Nucleic acids, which are critical components for inheriting genetic information in all species including pathogens, are key structures sensed by the innate immune system. The corresponding receptors for foreign nucleic acids include members of Tollâ€like receptors, RIGâ€Iâ€like receptors, and intracellular DNA sensors. While nucleic acid recognition by these receptors is required for host defense against the pathogen, there is a potential risk to the host of selfâ€nucleic acids recognition, thus precipitating autoimmune and autoinflammatory diseases. In this review, we discuss the roles of nucleic acidâ€sensing receptors in guarding against pathogen invasion, discriminating between self and nonâ€self, and contributing to autoimmunity and autoinflammatory diseases.
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