Author: Furth, Noa; Shilo, Shay; Cohen, Niv; Erez, Nir; Fedyuk, Vadim; Schrager, Alexander M.; Weinberger, Adina; Dror, Amiel A.; Zigron, Asaf; Shehadeh, Mona; Sela, Eyal; Srouji, Samer; Amit, Sharon; Levy, Itzchak; Segal, Eran; Dahan, Rony; Jones, Dan; Douek, Daniel C.; Shema, Efrat
Title: Unified platform for genetic and serological detection of COVID-19 with single-molecule technology Cord-id: jlry0xa6 Document date: 2021_7_26
ID: jlry0xa6
Snippet: The COVID-19 pandemic raises the need for diverse diagnostic approaches to rapidly detect different stages of viral infection. The flexible and quantitative nature of single-molecule imaging technology renders it optimal for development of new diagnostic tools. Here we present a proof-of-concept for a single-molecule based, enzyme-free assay for detection of SARS-CoV-2. The unified platform we developed allows direct detection of the viral genetic material from patients’ samples, as well as th
Document: The COVID-19 pandemic raises the need for diverse diagnostic approaches to rapidly detect different stages of viral infection. The flexible and quantitative nature of single-molecule imaging technology renders it optimal for development of new diagnostic tools. Here we present a proof-of-concept for a single-molecule based, enzyme-free assay for detection of SARS-CoV-2. The unified platform we developed allows direct detection of the viral genetic material from patients’ samples, as well as their immune response consisting of IgG and IgM antibodies. Thus, it establishes a platform for diagnostics of COVID-19, which could also be adjusted to diagnose additional pathogens.
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