Selected article for: "pathogen detection and real time"

Author: Jillian N Whelan; Joshua Hatterschide; David M. Renner; Beihua Dong; Robert H Silverman; Susan R Weiss
Title: The host antiviral ribonuclease L protein supports Zika virus replication factory formation to enhance infectious virus production
  • Document date: 2019_11_24
  • ID: f9mpkzni_13
    Snippet: and RNase L KO cells. At 20hpi, expression of both ZIKV dsRNA and NS3 was increased 150 in WT cells, as measured by mean dsRNA and NS3 intensity at perinuclear ER sites 151 characteristic of flaviviruses ( Figure 2AB&C) . We also observed a change in localization 152 of ZIKV dsRNA and NS3 in RNase L KO cells, both of which were more disseminated 153 around the nucleus and into the cytoplasm. We used circularity and diameter parameters 154 to quan.....
    Document: and RNase L KO cells. At 20hpi, expression of both ZIKV dsRNA and NS3 was increased 150 in WT cells, as measured by mean dsRNA and NS3 intensity at perinuclear ER sites 151 characteristic of flaviviruses ( Figure 2AB&C) . We also observed a change in localization 152 of ZIKV dsRNA and NS3 in RNase L KO cells, both of which were more disseminated 153 around the nucleus and into the cytoplasm. We used circularity and diameter parameters 154 to quantify the spread of viral products throughout the cell at 20hpi, and determined that 155

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