Author: Mourier, Tobias; Sadykov, Mukhtar; Carr, Michael J.; Gonzalez, Gabriel; Hall, William W.; Pain, Arnab
Title: Host-directed editing of the SARS-CoV-2 genome Cord-id: qoejvdnb Document date: 2020_11_5
ID: qoejvdnb
Snippet: The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and
Document: The extensive sequence data generated from SARS-CoV-2 during the 2020 pandemic has facilitated the study of viral genome evolution over a brief period of time. This has highlighted instances of directional mutation pressures exerted on the SARS-CoV-2 genome from host antiviral defense systems. In this brief review we describe three such human defense mechanisms, the apolipoprotein B mRNA editing catalytic polypeptide-like proteins (APOBEC), adenosine deaminase acting on RNA proteins (ADAR), and reactive oxygen species (ROS), and discuss their potential implications on SARS-CoV-2 evolution.
Search related documents:
Co phrase search for related documents- adar1 activity and adenosine deamination: 1
Co phrase search for related documents, hyperlinks ordered by date