Author: Patel, Maulin; Dominguez, Eduardo; Sacher, Daniel; Desai, Parag; Chandar, Ashwin; Bromberg, Michael; Caricchio, Roberto; Criner, Gerard J.
Title: Etoposide as Salvage Therapy for Cytokine Storm due to COVID-19 Cord-id: brqyf7kp Document date: 2020_9_12
ID: brqyf7kp
Snippet: COVID-19 has resulted in significant morbidity and mortality due to lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to Etoposide. Thus, Etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first re
Document: COVID-19 has resulted in significant morbidity and mortality due to lack of effective therapies. Therapeutic strategies under investigation target the overactive cytokine response with anti-cytokine or immunomodulators therapies. We present a unique case of severe cytokine storm resistant to multiple anti-cytokine therapies, but eventually responsive to Etoposide. Thus, Etoposide may have a role as salvage therapy in treatment of cytokine storm in COVID-19. To our knowledge, this is the first reported case of use of Etoposide in COVID-19.
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