Author: yongwen chen; Zeqing Feng; Bo Diao; Rongshuai Wang; Gang Wang; Chenhui Wang; Yingjun Tan; Liang Liu; Changsong Wang; Ying Liu; Yueping Liu; Zilin Yuan; Liang Ren; Yuzhang Wu
Title: The Novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Directly Decimates Human Spleens and Lymph Nodes Document date: 2020_3_31
ID: dvpqkmnh_16
Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint Immunohistochemistry showed that SARS-CoV-2 NP antigens could be seen in spleens and LNs from all of these six autopsies, while being absent in sections from normal healthy controls. In the spleen, viral NP + cells were primarily distributed in red pulp and blood vessels, although positive cells were also occasionally observed in white pulp. In lymph nodes, the NP + cells.....
Document: is the (which was not peer-reviewed) The copyright holder for this preprint Immunohistochemistry showed that SARS-CoV-2 NP antigens could be seen in spleens and LNs from all of these six autopsies, while being absent in sections from normal healthy controls. In the spleen, viral NP + cells were primarily distributed in red pulp and blood vessels, although positive cells were also occasionally observed in white pulp. In lymph nodes, the NP + cells were seen in cells within marginal sinus of lymph nodules as well as capillaries, some positive cells are also found in germinal centers, and NP antigen was observed in cytoplasm, whereas nucleus is negative for NP expression (Figure 2A) .
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