Author: Shu-Miaw Chaw; Jui-Hung Tai; Shi-Lun Chen; Chia-Hung Hsieh; Sui-Yuan Chang; Shiou-Hwei Yeh; Wei-Shiung Yang; Pei-Jer Chen; Hurng-Yi Wang
Title: The origin and underlying driving forces of the SARS-CoV-2 outbreak Document date: 2020_4_14
ID: bawgldfi_12
Snippet: However, dN/dS was smaller in episode I than in episode II across the majority of the 203 genome, suggesting that elevation of dN/dS is probably mostly due to the relaxation of 204 selection. We further divided episode I into Ia and Ib, according to the appearance of 84S in 205 orf8 protein on 1/6/2020. The genome-wide dN/dS values were 0.27 and 0.23 for episode 1a 206 and 1b, respectively (S1 Table) . Therefore, as shown in the frequency spectra.....
Document: However, dN/dS was smaller in episode I than in episode II across the majority of the 203 genome, suggesting that elevation of dN/dS is probably mostly due to the relaxation of 204 selection. We further divided episode I into Ia and Ib, according to the appearance of 84S in 205 orf8 protein on 1/6/2020. The genome-wide dN/dS values were 0.27 and 0.23 for episode 1a 206 and 1b, respectively (S1 Table) . Therefore, as shown in the frequency spectra, the signature 207 of positive selection is weak at the early stage of the epidemic.
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