Author: Feria Hikmet; Loren Méar; Mathias Uhlén; Cecilia Lindskog
Title: The protein expression profile of ACE2 in human tissues Document date: 2020_4_3
ID: 4fz6iqwy_20
Snippet: All studied datasets confirm a consistent high expression in the intestinal tract, gallbladder and kidney. Further studies are needed to explore the potential involvement of ACE2 in the manifestation of symptoms related to these organs as a result of COVID-19 disease. In addition to respiratory symptoms, the closely related SARS-CoV that caused the SARS outbreak was shown to also cause diarrhea, impaired liver function and elevation of non-cardia.....
Document: All studied datasets confirm a consistent high expression in the intestinal tract, gallbladder and kidney. Further studies are needed to explore the potential involvement of ACE2 in the manifestation of symptoms related to these organs as a result of COVID-19 disease. In addition to respiratory symptoms, the closely related SARS-CoV that caused the SARS outbreak was shown to also cause diarrhea, impaired liver function and elevation of non-cardiac creatine kinase, suggesting tropism of the virus to other organs well in line with the tissues showing the highest expression levels of ACE2. Interestingly, in a recent study on pediatric COVID-19 individuals, eight out of 10 cases showed rectal swabs positive for SARS-CoV-2, suggesting that the gastrointestinal tract may shed virus and that fecal-oral transmission may be a possible route for infection 27 . It should also be noted that the prerequisites of the interplay between SARS-CoV-2 attachment pattern to human cell surface receptors and COVID-19 disease progression are multifactorial, including not only the binding of the virus to the target cells, but also other factors such as the host's immune system and the total virus load. The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.31.016048 doi: bioRxiv preprint
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