Author: Feria Hikmet; Loren Méar; Mathias Uhlén; Cecilia Lindskog
Title: The protein expression profile of ACE2 in human tissues Document date: 2020_4_3
ID: 4fz6iqwy_21
Snippet: In summary, based on multiple datasets on the mRNA and protein level, using both single cell methods and larger tissue extracts, we here show that ACE2 expression in human tissues is mainly localized to microvilli of intestine and renal proximal tubules, gallbladder epithelium, testicular Sertoli cells and Leydig cells, glandular cells of seminal vesicle and cardiomyocytes. Several additional locations suggested by previous studies, including exp.....
Document: In summary, based on multiple datasets on the mRNA and protein level, using both single cell methods and larger tissue extracts, we here show that ACE2 expression in human tissues is mainly localized to microvilli of intestine and renal proximal tubules, gallbladder epithelium, testicular Sertoli cells and Leydig cells, glandular cells of seminal vesicle and cardiomyocytes. Several additional locations suggested by previous studies, including expression in AT2 cells, could not be confirmed. This raises questions regarding the role of ACE2 for infection of human lungs, and highlights the need to further explore the route of transmission during SARS-CoV-2 infection to understand the biology of the disease and to aid in the development of effective treatments to the viral infection.
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