Author: Brian D Quinlan; Huihui Mou; Lizhou Zhang; Yan Gao; Wenhui He; Amrita Ojha; Mark S Parcells; Guangxiang Luo; Wenhui Li; Guocai Zhong; Hyeryun Choe; Michael Farzan
Title: The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement Document date: 2020_4_12
ID: fnguelau_18
Snippet: Second, coronaviruses in general, and clearly SARS-CoV-2 in particular, transmits to a new host more rapidly than an adaptive immune response can emerge. A likely consequence of this strategy is that one of its most critical epitopes, namely its RBD, is exposed on the virion (Li, 2016; Walls et al., 2020; Wong et al., 2004; Wrapp et al., 2020) , favoring transmission efficiency over antibody resistance. Finally, the stability and compactness of t.....
Document: Second, coronaviruses in general, and clearly SARS-CoV-2 in particular, transmits to a new host more rapidly than an adaptive immune response can emerge. A likely consequence of this strategy is that one of its most critical epitopes, namely its RBD, is exposed on the virion (Li, 2016; Walls et al., 2020; Wong et al., 2004; Wrapp et al., 2020) , favoring transmission efficiency over antibody resistance. Finally, the stability and compactness of the SARS-CoV-1 and SARS-CoV-2 RBD means that it can be easily manufactured and presented to the immune system using many production technologies, presentation scaffolds, and delivery systems (Wong et al., 2004) .
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