Author: Brian D Quinlan; Huihui Mou; Lizhou Zhang; Yan Gao; Wenhui He; Amrita Ojha; Mark S Parcells; Guangxiang Luo; Wenhui Li; Guocai Zhong; Hyeryun Choe; Michael Farzan
Title: The SARS-CoV-2 receptor-binding domain elicits a potent neutralizing response without antibody-dependent enhancement Document date: 2020_4_12
ID: fnguelau_18
Snippet: Second, coronaviruses in general, and clearly SARS-CoV-2 in particular, transmits to a new host more rapidly than an adaptive immune response can emerge. A likely consequence of this strategy is that one of its most critical epitopes, namely its RBD, is exposed on the virion (Li, 2016; Walls et al., 2020; Wong et al., 2004; Wrapp et al., 2020) , favoring transmission efficiency over antibody resistance. Finally, the stability and compactness of t.....
Document: Second, coronaviruses in general, and clearly SARS-CoV-2 in particular, transmits to a new host more rapidly than an adaptive immune response can emerge. A likely consequence of this strategy is that one of its most critical epitopes, namely its RBD, is exposed on the virion (Li, 2016; Walls et al., 2020; Wong et al., 2004; Wrapp et al., 2020) , favoring transmission efficiency over antibody resistance. Finally, the stability and compactness of the SARS-CoV-1 and SARS-CoV-2 RBD means that it can be easily manufactured and presented to the immune system using many production technologies, presentation scaffolds, and delivery systems (Wong et al., 2004) .
Search related documents:
Co phrase search for related documents- adaptive immune response and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- adaptive immune response and immune system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- adaptive immune response and immune system present: 1
- adaptive immune response and new host: 1, 2, 3
- adaptive immune response and presentation scaffold: 1
- antibody resistance and critical epitope: 1
- antibody resistance and immune response: 1, 2, 3, 4, 5
- antibody resistance and immune system: 1, 2
- compactness stability and new host: 1
- critical epitope and immune response: 1, 2, 3
- delivery system and immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- delivery system and immune system: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- delivery system and immune system present: 1
- delivery system and new host: 1, 2, 3
- delivery system and new host transmit: 1
- immune response and likely consequence: 1, 2
- immune response and new host: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- immune response and presentation scaffold: 1
- immune system and presentation scaffold: 1
Co phrase search for related documents, hyperlinks ordered by date