Author: Erik Procko
Title: The sequence of human ACE2 is suboptimal for binding the S spike protein of SARS coronavirus 2 Document date: 2020_3_17
ID: jalijjmg_11
Snippet: are anticorrelated with the nCoV-S-Low sorts, with the exception of nonsense mutations 107 which were appropriately depleted from both gates. This indicates that most, but not all, 108 nonsynonymous mutations in ACE2 did not eliminate surface expression. The library is 109 biased towards solvent-exposed residues and has few substitutions of buried hydrophobics 110 that might have bigger effects on plasma membrane trafficking (33). 111 The copyrig.....
Document: are anticorrelated with the nCoV-S-Low sorts, with the exception of nonsense mutations 107 which were appropriately depleted from both gates. This indicates that most, but not all, 108 nonsynonymous mutations in ACE2 did not eliminate surface expression. The library is 109 biased towards solvent-exposed residues and has few substitutions of buried hydrophobics 110 that might have bigger effects on plasma membrane trafficking (33). 111 The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.16.994236 doi: bioRxiv preprint both nCoV-S-Low sorts (F). Conservation scores are calculated from the mean of the log 2 124 enrichment ratios for all amino acid substitutions at each residue position.
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