Author: Hazel Stewart; Katherine Brown; Adam M. Dinan; Nerea Irigoyen; Eric J. Snijder; Andrew E. Firth
Title: The transcriptional and translational landscape of equine torovirus Document date: 2018_4_7
ID: mozfm5ds_4
Snippet: Toroviruses infect cattle, goats, pigs and horses worldwide and can cause 32 gastrointestinal disease. There is no treatment or vaccine and their ability to spill 33 over into humans has not been assessed. These viruses are related to important 34 human pathogens including severe acute respiratory syndrome (SARS) coronavirus 35 and they share some common features, however the mechanism that they use to 36 produce subgenomic RNA molecules differs......
Document: Toroviruses infect cattle, goats, pigs and horses worldwide and can cause 32 gastrointestinal disease. There is no treatment or vaccine and their ability to spill 33 over into humans has not been assessed. These viruses are related to important 34 human pathogens including severe acute respiratory syndrome (SARS) coronavirus 35 and they share some common features, however the mechanism that they use to 36 produce subgenomic RNA molecules differs. Here we performed deep sequencing to 37 determine how equine torovirus produces subgenomic RNAs. In doing so, we also 38 identified two previously unknown open reading frames "hidden" within the 39 genome. Together these results highlight the similarities and differences between 40 this domestic animal virus and related pathogens of humans and livestock. 41
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