Author: Xavier Hernandez-Alias; Martin Schaefer; Luis Serrano
Title: Translational adaptation of human viruses to the tissues they infect Document date: 2020_4_7
ID: 0rk2dw4e_11
Snippet: Based on the RCU differences between viruses with distinct tropism, we hypothesize that distinct tissues impose selection towards a certain set of translationally-efficient codons. However, a validation for this hypothesis requires the accurate quantification of tissue-specific tRNA profiles, which has been hitherto missing. With the advent of such high-throughput expression data 27, 28 , here we retrieved the previously-published Supply-to-Deman.....
Document: Based on the RCU differences between viruses with distinct tropism, we hypothesize that distinct tissues impose selection towards a certain set of translationally-efficient codons. However, a validation for this hypothesis requires the accurate quantification of tissue-specific tRNA profiles, which has been hitherto missing. With the advent of such high-throughput expression data 27, 28 , here we retrieved the previously-published Supply-to-Demand Adaptation (SDA) estimate for translational efficiency 2 , which computes the balance between the supply (i.e., the anticodon tRNA abundances) and demand (i.e., the codons expressed in mRNAs) of each codon (see Methods).
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