Selected article for: "acute respiratory syndrome and add protein"
Author: Schulze, Kai; Staib, Caroline; Schätzl, Hermann M.; Ebensen, Thomas; Erfle, Volker; Guzman, Carlos A.
Title: A prime-boost vaccination protocol optimizes immune responses against the nucleocapsid protein of the SARS coronavirus
  • Cord-id: bwli875x
  • Document date: 2008_12_2
    • ID: bwli875x
    Snippet: Severe acute respiratory syndrome (SARS) is a serious infectious disease caused by the SARS coronavirus. We assessed the potential of prime-boost vaccination protocols based on the nucleocapsid (NC) protein co-administered with a derivative of the mucosal adjuvant MALP-2 or expressed by modified Vaccinia virus Ankara (MVA–NC) to stimulate humoral and cellular immune responses at systemic and mucosal levels. The obtained results demonstrated that strong immune responses can be elicited both at
    Document: Severe acute respiratory syndrome (SARS) is a serious infectious disease caused by the SARS coronavirus. We assessed the potential of prime-boost vaccination protocols based on the nucleocapsid (NC) protein co-administered with a derivative of the mucosal adjuvant MALP-2 or expressed by modified Vaccinia virus Ankara (MVA–NC) to stimulate humoral and cellular immune responses at systemic and mucosal levels. The obtained results demonstrated that strong immune responses can be elicited both at systemic and mucosal levels following a heterologous prime-boost vaccination protocol consisting in priming with NC protein add-mixed with MALP-2 by intranasal route and boosting with MVA–NC by intramuscular route.

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