Selected article for: "active virus and low frequency"
Author: Satria P. Sajuthi; Peter DeFord; Nathan D. Jackson; Michael T. Montgomery; Jamie L. Everman; Cydney L. Rios; Elmar Pruesse; James D. Nolin; Elizabeth G. Plender; Michael E. Wechsler; Angel CY Mak; Celeste Eng; Sandra Salazar; Vivian Medina; Eric M. Wohlford; Scott Huntsman; Deborah A. Nickerson; Soren Germer; Michael C. Zody; Gonçalo Abecasis; Hyun Min Kang; Kenneth M. Rice; Rajesh Kumar; Sam Oh; Jose Rodriguez-Santana; Esteban G. Burchard; Max A. Seibold
Title: Type 2 and interferon inflammation strongly regulate SARS-CoV-2 related gene expression in the airway epithelium
  • Document date: 2020_4_10
    • ID: mj8ebo7i_3
    Snippet: Strikingly, we found that 78% of interferon-high subjects were virus carriers compared to 251 only 10% of interferon-low subjects. These results demonstrate how asymptomatic virus 252 carriage nonetheless stimulates an active viral response that includes ACE2. Similar analysis of the TMPRSS2 eQTL variants yielded three independent eQTL 276 variants (rs1475908 AF=20%, rs74659079 AF=4%, and rs2838057 AF=13%, Figure 277 5b). The eQTL variant rs1475.....
    Document: Strikingly, we found that 78% of interferon-high subjects were virus carriers compared to 251 only 10% of interferon-low subjects. These results demonstrate how asymptomatic virus 252 carriage nonetheless stimulates an active viral response that includes ACE2. Similar analysis of the TMPRSS2 eQTL variants yielded three independent eQTL 276 variants (rs1475908 AF=20%, rs74659079 AF=4%, and rs2838057 AF=13%, Figure 277 5b). The eQTL variant rs1475908 was associated with a decrease in TMPRSS2 278 expression (log 2 A FC =-0.37, Figure 5d ), whereas both the rs74659079 and rs2838057 279 was only present in people of African descent and at a low frequency (AF=0.7%, Figure 285 5e). In contrast, the TMPRSS2 eQTL variant associated with decreased expression, 286 rs1475908, occurred across all world populations, with the highest allele frequencies 287 among East Asians (AF=38%), Europeans (AF=35%), intermediate frequencies among 288 Africans (AF=26%) and Ashkenazi Jews (AF=23%), and the lowest frequency among 289

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