Selected article for: "cold chain and large scale"
Author: Estefania Nunez-Bajo; Michael Kasimatis; Yasin Cotur; Tarek Asfour; Alex Collins; Ugur Tanriverdi; Max Grell; Matti Kaisti; Guglielmo Senesi; Karen Stevenson; Firat Guder
Title: Ultra-Low-Cost Integrated Silicon-based Transducer for On-Site, Genetic Detection of Pathogens
  • Document date: 2020_3_25
    • ID: 7a3wdduq_3
    Snippet: Unlike other biomarkers, such as antibodies or non-genetic molecules originating from pathogens, NA can be chemically amplified, enabling direct detection of low numbers of pathogens (down to single organisms). Hence tests targeting NA tend to be exceptionally sensitive. NA-based reagents (e.g., primers) for NA testing can also be produced synthetically rapidly and on a large scale; DNA-based molecules, in particular, are highly stable, therefore.....
    Document: Unlike other biomarkers, such as antibodies or non-genetic molecules originating from pathogens, NA can be chemically amplified, enabling direct detection of low numbers of pathogens (down to single organisms). Hence tests targeting NA tend to be exceptionally sensitive. NA-based reagents (e.g., primers) for NA testing can also be produced synthetically rapidly and on a large scale; DNA-based molecules, in particular, are highly stable, therefore, do not require a cold-chain for storage, making it especially suitable for PoN testing. 1 Ability to produce NA quickly also increases the speed of development and deployment of new test kits to health systems, providing much needed diagnostic capabilities for the detection of novel pathogens (such as SARS-CoV-2). Despite the massive advantages, on-site testing of NA has been limited.

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