Selected article for: "antiviral effect and inhibitory effect"
Author: Takano, Tomomi; Katoh, Yasuichiroh; Doki, Tomoyoshi; Hohdatsu, Tsutomu
Title: Effect of chloroquine on feline infectious peritonitis virus infection in vitro and in vivo
  • Cord-id: 5t8yuq4v
  • Document date: 2013_5_3
    • ID: 5t8yuq4v
    Snippet: Feline infectious peritonitis (FIP) is a feline coronavirus-induced fatal disease in domestic and wild cats. Several studies have investigated potential treatments for FIP. However, there have been no reports on agents that have exhibited a therapeutic effect. Recently, chloroquine has been reported to antiviral effect. We investigated whether chloroquine can be used to treat FIP in vitro and in vivo. It was demonstrated that chloroquine has inhibitory effect against the replication of FIPV and
    Document: Feline infectious peritonitis (FIP) is a feline coronavirus-induced fatal disease in domestic and wild cats. Several studies have investigated potential treatments for FIP. However, there have been no reports on agents that have exhibited a therapeutic effect. Recently, chloroquine has been reported to antiviral effect. We investigated whether chloroquine can be used to treat FIP in vitro and in vivo. It was demonstrated that chloroquine has inhibitory effect against the replication of FIPV and anti-inflammatory effect in vitro. In vivo study using cats with experimentally induced FIP, the clinical score of chloroquine-treatment groups were better than in chloroquine-untreated group. However, alanine aminotransferase levels increased in the chloroquine-treated groups. It will be necessary to further investigate the possibility of FIP treatment with a combination of chloroquine and other agents.

    Search related documents:
    Co phrase search for related documents
    • acute sars cov respiratory syndrome coronavirus and ade phenomenon: 1, 2
    • acute sars cov respiratory syndrome coronavirus and administration timing: 1, 2, 3, 4, 5, 6, 7, 8
    • acute sars cov respiratory syndrome coronavirus and location length: 1
    • acute sars cov respiratory syndrome coronavirus and low cytotoxic: 1, 2, 3, 4