Author: Netea, Mihai G.; DomÃnguez-Andrés, Jorge; Barreiro, Luis B.; Chavakis, Triantafyllos; Divangahi, Maziar; Fuchs, Elaine; Joosten, Leo A. B.; van der Meer, Jos W. M.; Mhlanga, Musa M.; Mulder, Willem J. M.; Riksen, Niels P.; Schlitzer, Andreas; Schultze, Joachim L.; Stabell Benn, Christine; Sun, Joseph C.; Xavier, Ramnik J.; Latz, Eicke
Title: Defining trained immunity and its role in health and disease Cord-id: pe3zfrpf Document date: 2020_3_4
ID: pe3zfrpf
Snippet: Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained im
Document: Immune memory is a defining feature of the acquired immune system, but activation of the innate immune system can also result in enhanced responsiveness to subsequent triggers. This process has been termed ‘trained immunity’, a de facto innate immune memory. Research in the past decade has pointed to the broad benefits of trained immunity for host defence but has also suggested potentially detrimental outcomes in immune-mediated and chronic inflammatory diseases. Here we define ‘trained immunity’ as a biological process and discuss the innate stimuli and the epigenetic and metabolic reprogramming events that shape the induction of trained immunity.
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