Author: Alejandro A Schäffer; Eneida Hatcher; Linda Yankie; Lara Shonkwiler; J Rodney Brister; Ilene Karsch-Mizrachi; Eric P Nawrocki
Title: VADR: validation and annotation of virus sequence submissions to GenBank Document date: 2019_11_22
ID: besvz92f_9
Snippet: In this work, we describe the design and implementation of a new reference-based general software tool called VADR (Viral Annotation DefineR), for the validation and annotation of virus sequences from characterized species that have an open (non-circular) genome less than 25Kb in length and for which a reference (e.g. RefSeq entry) exists. We discuss the use of VADR in evaluating GenBank submissions of norovirus and dengue virus sequences. We com.....
Document: In this work, we describe the design and implementation of a new reference-based general software tool called VADR (Viral Annotation DefineR), for the validation and annotation of virus sequences from characterized species that have an open (non-circular) genome less than 25Kb in length and for which a reference (e.g. RefSeq entry) exists. We discuss the use of VADR in evaluating GenBank submissions of norovirus and dengue virus sequences. We compare VADR performance with that of VAPiD and VIGOR and show how it identifies more potential problems with sequences, making it more appropriate for use by GenBank indexers interested in manually reviewing those problems prior to sequence deposition.
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