Author: David N. Frick; Rajdeep S. Virdi; Nemanja Vuksanovic; Narayan Dahal; Nicholas R Silvaggi
Title: Variable Macro X Domain of SARS-CoV-2 Retains the Ability to Bind ADP-ribose Document date: 2020_4_2
ID: 02q9y011_26
Snippet: The SARS-CoV-2 rep 1ab peptide sequence was aligned with each of the PDB files listed, which describe an atomic structure of a homologous region of the SARS-CoV-1 rep 1ab polyprotein. Nsp's are shown in sequence as black arrows (note: there is no "nsp11", and the translational frameshift occurs after nsp10). The percent of amino that differ in each protein is plotted. For details see Fig. S1 (supporting information). Nsp1 is and interferon antag.....
Document: The SARS-CoV-2 rep 1ab peptide sequence was aligned with each of the PDB files listed, which describe an atomic structure of a homologous region of the SARS-CoV-1 rep 1ab polyprotein. Nsp's are shown in sequence as black arrows (note: there is no "nsp11", and the translational frameshift occurs after nsp10). The percent of amino that differ in each protein is plotted. For details see Fig. S1 (supporting information). Nsp1 is and interferon antagonist. 26 The Nsp3 X domain is studied here, the Nsp3 SUD consists of tandem macrodomains that bind G-quadruplex structures, 3 Nsp dC is the C-terminus of the SUD, 27 Nsp3pro is a papain-like protease, 28 and Nsp3 RBD is another possible RNA binding domain. 29 Nsp5 is the main viral protease. 30 author/funder. All rights reserved. No reuse allowed without permission.
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