Author: Mao, Kaimin; Tan, Qi; Ma, Yanling; Wang, Sufei; Zhong, Hua; Liao, Yuhan; Huang, Qi; Xiao, Wenjing; Xia, Hui; Tan, Xueyun; Luo, Ping; Xu, Juanjuan; Long, Danling; Jin, Yang
Title: Proteomics of extracellular vesicles in plasma reveals the characteristics and residual traces of COVID-19 patients without underlying diseases after 3 months of recovery Cord-id: 78g6yr71 Document date: 2021_5_25
ID: 78g6yr71
Snippet: More and more patients suffered from Coronavirus disease 2019 (COVID-19) have got recovery gradually due to suitable intervention. Increasing data mainly studies the clinical characteristics of recovered COVID-19 patients, and their molecular changes especially proteome changes also play the same important role in understanding of biological characteristics of recovered COVID-19 patients as clinical characteristics do. In our study, we reported the whole lung-ground glass-CT value-average of mil
Document: More and more patients suffered from Coronavirus disease 2019 (COVID-19) have got recovery gradually due to suitable intervention. Increasing data mainly studies the clinical characteristics of recovered COVID-19 patients, and their molecular changes especially proteome changes also play the same important role in understanding of biological characteristics of recovered COVID-19 patients as clinical characteristics do. In our study, we reported the whole lung-ground glass-CT value-average of mild/severe recovered patients 3 months after discharge without underlying diseases was significantly lower than that of healthy subjects. Then we isolated the extracellular vesicles (EVs) of plasma from 19 healthy subjects and 67 recovered COVID-19 patients. Mass Spectrometry was used to catalogue the proteins of these EVs compared to a defined group of controls. Identified 174 proteins were differentially expressed in the EVs of COVID-19 patients compared with healthy subjects, which involved in lipid metabolic process, response to cellular, and response to stress oxygen-containing compound. Besides, we identified several protein of plasma EVs in recovered patients associated with coagulation activity, inflammatory reaction, immune response, and low organ function. In addition, proteins correlating with clinical index such as alkaline phosphatase (ALP) and alanine aminotransferase (ALT) were also detected. Moreover, we also identified many unique or characteristic associations found in the recovered COVID-19 patients, which especially involved the kidney, serum electrolyte levels, and inflammation functions. This finding suggests that monitoring the situation of recovered patients might be useful, especially the indexes of coagulation, inflammation, immunity, and organ function, which can prevent bleeding, reinfection and organ dysfunction.
Search related documents:
Co phrase search for related documents- acid glycoprotein and acute phase protein: 1, 2, 3, 4, 5, 6, 7, 8
- acid glycoprotein and acute stage: 1
- acid metabolism and acute phase: 1
- acid metabolism and acute stage: 1
- acid receptor and acute phase: 1, 2
- acn solvent and acquisition mode: 1
Co phrase search for related documents, hyperlinks ordered by date