Author: Christiansen, Anders; Dyrskjøt, Lars
Title: The functional role of the novel biomarker karyopherin α 2 (KPNA2) in cancer Cord-id: 5xyfrru7 Document date: 2013_4_30
ID: 5xyfrru7
Snippet: In recent years, Karyopherin α 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. The aberrant high levels observed in cancer tissue have been associated with adverse patient characteristics, prompting the idea that KPNA2 plays a role in carcinogenesis. This notion is supported by studies in cancer cells, where KPNA2 deregulation has been demonstrated to affect malignant transformation. By virtue of its role in nucleocytoplasmic transport, KPNA2 is implicated in the transl
Document: In recent years, Karyopherin α 2 (KPNA2) has emerged as a potential biomarker in multiple cancer forms. The aberrant high levels observed in cancer tissue have been associated with adverse patient characteristics, prompting the idea that KPNA2 plays a role in carcinogenesis. This notion is supported by studies in cancer cells, where KPNA2 deregulation has been demonstrated to affect malignant transformation. By virtue of its role in nucleocytoplasmic transport, KPNA2 is implicated in the translocation of several cancer-associated proteins. We provide an overview of the clinical studies that have established the biomarker potential of KPNA2 and describe its functional role with an emphasis on established associations with cancer.
Search related documents:
Co phrase search for related documents- aberrant activation and lung cancer: 1, 2
- aberrant activation and lymphocyte activation: 1
- aberrant expression and liver cancer: 1, 2
- aberrant expression and lung cancer: 1, 2, 3, 4, 5, 6
- aberrant expression and lung cancer cell: 1, 2
- aberrant expression and machinery target: 1
Co phrase search for related documents, hyperlinks ordered by date