Author: Villalba, MarÃa Caridad Montalvo; Ramirez, Odalys Valdés; Jiménez, Mayra Muné; Garcia, Amely Arencibia; Alfonso, Javier Martinez; Baez, Guelsy González; Arrieta, Rosmery Roque; Simón, Dianelvys Rosell; Gainza, Delmis Alvárez; Vazquez, Beatriz Sierra; Aguirre, Sonia Resik; Tirado, Maria Guadalupe Guzmán
Title: Interferon gamma, TGF-β1 and RANTES expression in upper airway samples from SARS-CoV-2 infected patients Cord-id: q34j4zxu Document date: 2020_8_29
ID: q34j4zxu
Snippet: Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and anti-inflammatory mediators plays an important role in the immunopathogenesis of Coronavirus Disease 2019 (COVID-19). The aim of this study was to evaluate the early inflammatory response in upper airway by measuring of IFN-γ, TGF-β1 and RANTES at mRNA level. Forty five SARS-CoV-2 infected patients were enrolled, whose were divided in two groups: asymptomatic and symptomatic. Twenty healthy persons, SAR
Document: Upper respiratory tract is the primary site of SARS-CoV-2 replication. Releasing of pro and anti-inflammatory mediators plays an important role in the immunopathogenesis of Coronavirus Disease 2019 (COVID-19). The aim of this study was to evaluate the early inflammatory response in upper airway by measuring of IFN-γ, TGF-β1 and RANTES at mRNA level. Forty five SARS-CoV-2 infected patients were enrolled, whose were divided in two groups: asymptomatic and symptomatic. Twenty healthy persons, SARS-CoV-2 negative were included as controls. Higher IFN-γ expression was detected in SARS-CoV-2 infected patients in comparison with controls (p = 0,0393). IFN-γ expression was increased in symptomatic patients (p = 0,0165). TGF-β1 and RANTES expressions were lower in SARS-CoV-2 infected patients than controls (p < 0,0001; p = 0,0011, respectively). A significant correlation between IFN-γ and TGF-β1 was observed in SARS-CoV-2 asymptomatic patients (r = +0,61, p = 0,0014). The findings suggest that imbalance between IFN-γ and TGF-β1 expression could be an impact in clinical expression of SARS-CoV-2 infection.
Search related documents:
Co phrase search for related documents- absence presence and adaptive immune response: 1, 2
- absence presence and adaptive immune response innate: 1
- absence presence and adaptive innate: 1, 2
- absence presence and adaptive innate immune response: 1
- absence presence and local increasing: 1
- activate immune cell and adaptive immune response: 1, 2
- activate immune cell and adaptive innate: 1, 2, 3
- activation recruitment and adaptive immune response: 1, 2, 3, 4
- activation recruitment and adaptive immune response innate: 1, 2, 3
- activation recruitment and adaptive innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14
- activation recruitment and adaptive innate immune response: 1, 2, 3
- activation regulate and adaptive immune response: 1
- activation regulate and adaptive immune response innate: 1
- activation regulate and adaptive innate: 1, 2, 3, 4, 5, 6
- activation regulate and adaptive innate immune response: 1
- adaptive immune response and local innate immune response: 1
Co phrase search for related documents, hyperlinks ordered by date