Author: Lovly, C. M.; Boyd, K. L.; Gonzalez-Ericsson, P. I.; Lowe, C. L.; Brown, H. M.; Hoffman, R. D.; Sterling, B. C.; Kapp, M. E.; Johnson, D. B.; Kopparapu, P. R.; Iams, W. T.; Warren, M. A.; Noto, M. J.; Rini, B. I.; Jagasia, M.; Das, S. R.; Balko, J. M.
Title: Rapidly fatal pneumonitis from immunotherapy and concurrent SARS-CoV-2 infection in a patient with newly diagnosed lung cancer Cord-id: lot1macw Document date: 2020_5_1
ID: lot1macw
Snippet: Immune checkpoint inhibitors (ICIs) are used for the treatment of numerous cancers, but risks associated with ICI-therapy during the COVID-19 pandemic are poorly understood. We report a case of acute lung injury in a lung cancer patient initially treated for ICI-pneumonitis and later found to have concurrent SARS-CoV-2 infection. Post-mortem analyses revealed diffuse alveolar damage in both the acute and organizing phases, with a predominantly CD68+ inflammatory infiltrate. Serum was positive fo
Document: Immune checkpoint inhibitors (ICIs) are used for the treatment of numerous cancers, but risks associated with ICI-therapy during the COVID-19 pandemic are poorly understood. We report a case of acute lung injury in a lung cancer patient initially treated for ICI-pneumonitis and later found to have concurrent SARS-CoV-2 infection. Post-mortem analyses revealed diffuse alveolar damage in both the acute and organizing phases, with a predominantly CD68+ inflammatory infiltrate. Serum was positive for anti-SARS-CoV-2 IgG, suggesting that viral infection predated administration of ICI-therapy and may have contributed to a more fulminant clinical presentation. These data suggest the need for routine SARS-CoV-2 testing in cancer patients, where clinical and radiographic evaluations may be non-specific.
Search related documents:
Co phrase search for related documents- active patient and acute pneumonia: 1, 2
- active patient and acute viral infection: 1
- active patient and liver lesion: 1
- active patient and lung cancer: 1, 2, 3, 4
- active patient and lung cancer patient: 1, 2
- active patient and lung injury: 1, 2
- active patient and lung specific: 1
- acute ards respiratory distress syndrome and additionally need: 1
- acute ards respiratory distress syndrome and low positive: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- acute ards respiratory distress syndrome and lung cancer: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16
- acute ards respiratory distress syndrome and lung cancer patient: 1
- acute ards respiratory distress syndrome and lung injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74, 75
- acute ards respiratory distress syndrome and lung injury pneumonitis: 1, 2
- acute ards respiratory distress syndrome and lung observe: 1
- acute ards respiratory distress syndrome and lung specific: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- acute ards respiratory distress syndrome and lymph node: 1, 2
- acute ards respiratory distress syndrome include and lung injury: 1, 2
- acute lung injury and additionally need: 1
- acute lung injury and low positive: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date