Selected article for: "activation process and macrophage activation"
Author: Choudhuri, Subhadip; Chowdhury, Imran Hussain; Garg, Nisha Jain
Title: Mitochondrial Regulation of Macrophage Response Against Pathogens
  • Cord-id: p63sb4gv
  • Document date: 2021_2_17
    • ID: p63sb4gv
    Snippet: Innate immune cells play the first line of defense against pathogens. Phagocytosis or invasion by pathogens can affect mitochondrial metabolism in macrophages by diverse mechanisms and shape the macrophage response (proinflammatory vs. immunomodulatory) against pathogens. Besides β-nicotinamide adenine dinucleotide 2'-phosphate, reduced (NADPH) oxidase, mitochondrial electron transport chain complexes release superoxide for direct killing of the pathogen. Mitochondria that are injured are remov
    Document: Innate immune cells play the first line of defense against pathogens. Phagocytosis or invasion by pathogens can affect mitochondrial metabolism in macrophages by diverse mechanisms and shape the macrophage response (proinflammatory vs. immunomodulatory) against pathogens. Besides β-nicotinamide adenine dinucleotide 2'-phosphate, reduced (NADPH) oxidase, mitochondrial electron transport chain complexes release superoxide for direct killing of the pathogen. Mitochondria that are injured are removed by mitophagy, and this process can be critical for regulating macrophage activation. For example, impaired mitophagy can result in cytosolic leakage of mitochondrial DNA (mtDNA) that can lead to activation of cGAS–STING signaling pathway of macrophage proinflammatory response. In this review, we will discuss how metabolism, mtDNA, mitophagy, and cGAS–STING pathway shape the macrophage response to infectious agents.

    Search related documents:
    Co phrase search for related documents
    • activate form and adaptive immunity: 1
    • activate kinase and adapter protein: 1
    • activate kinase and adaptive immune system: 1
    • activate kinase and adaptive immune system innate: 1
    • activate receptor and adaptive immune system: 1
    • activate receptor and adaptive immunity: 1
    • activation recruitment and adaptive immune system: 1, 2, 3, 4, 5, 6
    • activation recruitment and adaptive immune system innate: 1, 2, 3, 4
    • activation recruitment and adaptive immunity: 1, 2, 3, 4, 5
    • activator transducer and adaptive immune system: 1
    • activator transducer and adaptive immunity: 1, 2
    • adaptive immunity and adenine dinucleotide: 1