A Multiscale and Comparative Model for Receptor Binding of 2019 Novel Coronavirus and the Implication of its Life Cycle in Host Cells

Zhaoqian Su; Yinghao Wu

We further incorporated the results derived from the rigid-body simulations into 3 the mathematical model to compare the viral life cycle in SARS and COVID-19. The 4 rigid-body simulation suggests that SARS-CoV binds to receptor ACE2 faster than 19-5 nCoV, given the same amount of time. Therefore, we applied the mathematical model to 6 two comparative systems. A relatively fast viral binding rate k b was adopted in the first 7 system to represent the binding process of SARS, while a relatively slow rate was 8 adopted in the second to represent the binding process of 2019-nCoV. All the other 9 parameters such as diffusion constants and concentrations in both systems remain the The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi. org/10.1101 org/10. /2020 between human receptor and S-proteins from different coronavirus in, and provided the 1 possible mechanism from the molecular level to their impacts on, regulating the 2 dynamics of the entire viral life cycle.