Mannose-binding lectin and risk of infections in type 2 diabetes: A Danish cohort study.

Gedebjerg, Anne; Thomsen, Reimar Wernich; Kjaergaard, Alisa Devedzic; Steffensen, Rudi; Nielsen, Jens Steen; Rungby, Jørgen; Friborg, Søren Gunnar; Brandslund, Ivan; Thiel, Steffen; Beck-Nielsen, Henning; Sørensen, Henrik Toft; Hansen, Troels Krarup; Bjerre, Mette

AIMS In individuals at increased risk of infections, e.g., patients with type 2 diabetes, low MBL may have detrimental effects. We used the Mendelian randomization principle to examine whether genetically low MBL is a risk factor for developing infections in patients with type 2 diabetes. METHODS Serum MBL (n = 7305) and MBL genotype (n = 3043) were determined in a nationwide cohort of patients with new type 2 diabetes and up to 8 years follow-up for hospital-treated infections and community-based antimicrobial prescriptions. The associations were examined in spline and Cox regression analyses. RESULTS 1140 patients (16%) were hospitalized with an infection and 5077 patients (70%) redeemed an antimicrobial prescription. For low (≤100 μg/L) versus intermediate (101-1000 μg/L) serum MBL concentration, the adjusted hazard ratios (aHRs) were 1.13(95% confidence interval, 0.96-1.33) for any hospital-treated infections and 1.19(1.01-1.41) for bacterial infections. Low MBL expression genotype was not associated with risk of any hospital-treated infections except for diarrheal diseases (aHR 2.23[1.04-4.80]). Low MBL expression genotype, but not low serum MBL, was associated with increased risk for antimicrobial prescriptions (aHR 1.18[1.04-2.34] and antibacterial prescriptions 1.20[1.05-1.36]). CONCLUSIONS Low MBL is a weak causal risk factor for developing infections in patients with type 2 diabetes.