Author: Kurreck, Jens
Title: RNA Interference: From Basic Research to Therapeutic Applications Cord-id: lthz75oc Document date: 2009_1_19
ID: lthz75oc
Snippet: An efficient mechanism for the sequenceâ€specific inhibition of gene expression is RNA interference. In this process, doubleâ€stranded RNA molecules induce cleavage of a selected target RNA (see picture). This technique has in recent years developed into a standard method of molecular biology. Successful applications in animal models have already led to the initiation of RNAiâ€based clinical trials as a new therapeutic option.[Image: see text] Only ten years ago Andrew Fire and Craig Mello we
Document: An efficient mechanism for the sequenceâ€specific inhibition of gene expression is RNA interference. In this process, doubleâ€stranded RNA molecules induce cleavage of a selected target RNA (see picture). This technique has in recent years developed into a standard method of molecular biology. Successful applications in animal models have already led to the initiation of RNAiâ€based clinical trials as a new therapeutic option.[Image: see text] Only ten years ago Andrew Fire and Craig Mello were able to show that doubleâ€stranded RNA molecules could inhibit the expression of homologous genes in eukaryotes. This process, termed RNA interference, has developed into a standard method of molecular biology. This Review provides an overview of the molecular processes involved, with a particular focus on the posttranscriptional inhibition of gene expression in mammalian cells, the possible applications in research, and the results of the first clinical studies.
Search related documents:
Co phrase search for related documents- Try single phrases listed below for: 1
Co phrase search for related documents, hyperlinks ordered by date