Author: Amir Saberi; Anastasia A. Gulyaeva; John L. Brubacher; Phillip A. Newmark; Alexander E. Gorbalenya
Title: A planarian nidovirus expands the limits of RNA genome size Document date: 2018_4_11
ID: gwgflckq_1
Snippet: Radiation of primitive life over its initial two billion years of evolution was likely accompanied by genome expansion and a proposed transition from RNA-based through RNA-protein to DNA-based life (1) . The feasibility of an autonomous ancient RNA genome and the mechanisms underlying such fateful transitions are challenging to reconstruct. It is especially unclear whether such RNA entities ever evolved genomes close to the 100-300 kilobases (kb).....
Document: Radiation of primitive life over its initial two billion years of evolution was likely accompanied by genome expansion and a proposed transition from RNA-based through RNA-protein to DNA-based life (1) . The feasibility of an autonomous ancient RNA genome and the mechanisms underlying such fateful transitions are challenging to reconstruct. It is especially unclear whether such RNA entities ever evolved genomes close to the 100-300 kilobases (kb) range (2, 3) of the "minimal" reconstructed cellular DNA genome (4) . This range overlaps with the upper size limit of nuclear pre-mRNAs (5) ; however, pre-mRNAs are incapable of self-replication, the defining property of primordial genomic RNAs.
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