Author: Carla Mavian; Simone Marini; Mattia Prosperi; Marco Salemi
Title: A snapshot of SARS-CoV-2 genome availability up to 30th March, 2020 and its implications Document date: 2020_4_5
ID: 8vl0okiv_6
Snippet: Lack of resolution and uncertainty in the SARS-CoV-2 phylogenetic tree is to be expected, considering that relatively little genetic diversity can be accumulated during the first three months of an epidemic, even for an exponentially spreading and fast-evolving RNA virus. Assessment of phylogenetic signal in the dataset was carried out using likelihood mapping analysis (11) , which estimates the likelihood of each of possible tree topology for an.....
Document: Lack of resolution and uncertainty in the SARS-CoV-2 phylogenetic tree is to be expected, considering that relatively little genetic diversity can be accumulated during the first three months of an epidemic, even for an exponentially spreading and fast-evolving RNA virus. Assessment of phylogenetic signal in the dataset was carried out using likelihood mapping analysis (11) , which estimates the likelihood of each of possible tree topology for any group of four sequences (quartet), randomly chosen from an alignment, and reports them inside an equilateral triangle (the likelihood map) where the corners represent distinct tree topologies and the center star-like trees.
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