Author: Janice M Leung; Chen Xi Yang; Anthony Tam; Tawimas Shaipanich; Tillie L Hackett; Gurpreet K Singhera; Delbert R Dorscheid; Don D Sin
Title: ACE-2 Expression in the Small Airway Epithelia of Smokers and COPD Patients: Implications for COVID-19 Document date: 2020_3_23
ID: ei2b8oqn_2
Snippet: COVID-19 displays symptoms ranging from mild to severe (pneumonia) that can lead to death in some individuals [2] [3] [4] . As of March 13, 2020, there have been 144,064 laboratory-confirmed cases of COVID-19 worldwide with 5,397 deaths worldwide [5] . SARS-CoV-2 uses the angiotensin converting enzyme II (ACE-2) as the cellular entry receptor [6] . While the virus can infect individuals of any age, to date, most of the severe cases have been desc.....
Document: COVID-19 displays symptoms ranging from mild to severe (pneumonia) that can lead to death in some individuals [2] [3] [4] . As of March 13, 2020, there have been 144,064 laboratory-confirmed cases of COVID-19 worldwide with 5,397 deaths worldwide [5] . SARS-CoV-2 uses the angiotensin converting enzyme II (ACE-2) as the cellular entry receptor [6] . While the virus can infect individuals of any age, to date, most of the severe cases have been described in those over the age of 55 years and with significant comorbidities such as chronic obstructive pulmonary disease (COPD) [7] . Here, we determined whether patients with COPD have increased expression of ACE-2 in bronchial epithelial cells in lower respiratory tract.
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