Author: Janice M Leung; Chen Xi Yang; Anthony Tam; Tawimas Shaipanich; Tillie L Hackett; Gurpreet K Singhera; Delbert R Dorscheid; Don D Sin
Title: ACE-2 Expression in the Small Airway Epithelia of Smokers and COPD Patients: Implications for COVID-19 Document date: 2020_3_23
ID: ei2b8oqn_20
Snippet: To our knowledge, our study is the first to demonstrate increased ACE-2 expression in airways of current (but not former) smokers and those with COPD. These results are also consistent with previous observations in small animals wherein smoke exposure has been shown to upregulate both the expression and activity of ACE-2 in the airways [19, 20] . While the up-regulation of ACE-2 may be useful in protecting the host against acute lung injury, chro.....
Document: To our knowledge, our study is the first to demonstrate increased ACE-2 expression in airways of current (but not former) smokers and those with COPD. These results are also consistent with previous observations in small animals wherein smoke exposure has been shown to upregulate both the expression and activity of ACE-2 in the airways [19, 20] . While the up-regulation of ACE-2 may be useful in protecting the host against acute lung injury, chronically, this may predispose individuals to increased risk of coronavirus infections, which uses this receptor to gain entrance into epithelial cells.
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