Author: Bruna GG Pinto; Antonio ER Oliveira; Youvika Singh; Leandro Jimenez; Andre NA Goncalves; Rodrigo LT Ogava; Rachel Creighton; Jean PS Peron; Helder I Nakaya
Title: ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19 Document date: 2020_3_27
ID: 2un9aggj_22
Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.03.21.20040261 doi: medRxiv preprint (Table S1 ) and to identify the differentially expressed genes (FDR < 0.01). b. Pathway enrichment analysis. Pathways from the "GO Biological Process 2018" database with Adjusted P-value < 0.05 were selected to create the network. The width of edges is proportional to the number of genes shared by two pat.....
Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.03.21.20040261 doi: medRxiv preprint (Table S1 ) and to identify the differentially expressed genes (FDR < 0.01). b. Pathway enrichment analysis. Pathways from the "GO Biological Process 2018" database with Adjusted P-value < 0.05 were selected to create the network. The width of edges is proportional to the number of genes shared by two pathways (nodes). The size and color of nodes are proportional to the -log10 Adjusted P-value. c. Genes from the "viral life cycle" pathway that were up-regulated in human diseases. The colors in the heat map represent the log2 fold-change between patients and control individuals.
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