Selected article for: "column chromatography and general procedure"
Author: Linlin Zhang; Daizong Lin; Yuri Kusov; Yong Nian; Qingjun Ma; Jiang Wang; Albrecht von Brunn; Pieter Leyssen; Kristina Lanko; Johan Neyts; Adriaan de Wilde; Eric J. Snijder; Hong Liu; Rolf Hilgenfeld
Title: Alpha-ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication
  • Document date: 2020_2_10
    • ID: 7n8p9okf_85
    Snippet: Synthesis of α-ketoamides 11 (general procedure). Compound 10 was dissolved in CH2Cl2, then Dess-Martin periodinane (74 mg, 0.176 mmol) and NaHCO3 (30 mg, 0.176 mmol) were added. The resulting mixture was stirred at 20 o C for 1 h. The mixture was concentrated and purified by column chromatography on silica gel (CH2Cl2/MeOH = 20/1) to give the a-ketoamides 11 as light yellow solid (52-79% in two steps)......
    Document: Synthesis of α-ketoamides 11 (general procedure). Compound 10 was dissolved in CH2Cl2, then Dess-Martin periodinane (74 mg, 0.176 mmol) and NaHCO3 (30 mg, 0.176 mmol) were added. The resulting mixture was stirred at 20 o C for 1 h. The mixture was concentrated and purified by column chromatography on silica gel (CH2Cl2/MeOH = 20/1) to give the a-ketoamides 11 as light yellow solid (52-79% in two steps).

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