Author: Ryan M. Carey; Jenna R. Freund; Benjamin M. Hariri; Nithin D. Adappa; James N. Palmer; Robert J. Lee
Title: Altered polarization of PAR-2 signaling during airway epithelial remodeling Document date: 2020_1_9
ID: 8iet67u3_3
Snippet: We first tested activation of PAR-2 by Aspergillus fumigatus, the most prevalent fungal cause of pulmonary allergic disease, including allergic bronchopulmonary aspergillosis associated with chronic lung injury in patients with cystic fibrosis (CF) or chronic asthma. 21 We next examined PAR-2 signaling in airway squamous cells using pharmacology and live cell imaging. We then tested PAR-2 signaling in well-differentiated air-liquid interface (ALI.....
Document: We first tested activation of PAR-2 by Aspergillus fumigatus, the most prevalent fungal cause of pulmonary allergic disease, including allergic bronchopulmonary aspergillosis associated with chronic lung injury in patients with cystic fibrosis (CF) or chronic asthma. 21 We next examined PAR-2 signaling in airway squamous cells using pharmacology and live cell imaging. We then tested PAR-2 signaling in well-differentiated air-liquid interface (ALI) cultures of primary nasal cells exposed to disease-related modifiers, including IL-13, cigarette smoke condensate (CSC), and retinoic acid deficiency, all of which alter epithelial morphology. We also examined isolated tissue from inflamed nasal polyp and compared it with control middle turbinate. The data below reveal important alterations of the polarity of PAR-2 signaling in squamous cells and primary epithelial cells de-differentiated through disease-relevant mechanisms.
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