Author: Ryan M. Carey; Jenna R. Freund; Benjamin M. Hariri; Nithin D. Adappa; James N. Palmer; Robert J. Lee
Title: Altered polarization of PAR-2 signaling during airway epithelial remodeling Document date: 2020_1_9
ID: 8iet67u3_3
Snippet: We first tested activation of PAR-2 by Aspergillus fumigatus, the most prevalent fungal cause of pulmonary allergic disease, including allergic bronchopulmonary aspergillosis associated with chronic lung injury in patients with cystic fibrosis (CF) or chronic asthma. 21 We next examined PAR-2 signaling in airway squamous cells using pharmacology and live cell imaging. We then tested PAR-2 signaling in well-differentiated air-liquid interface (ALI.....
Document: We first tested activation of PAR-2 by Aspergillus fumigatus, the most prevalent fungal cause of pulmonary allergic disease, including allergic bronchopulmonary aspergillosis associated with chronic lung injury in patients with cystic fibrosis (CF) or chronic asthma. 21 We next examined PAR-2 signaling in airway squamous cells using pharmacology and live cell imaging. We then tested PAR-2 signaling in well-differentiated air-liquid interface (ALI) cultures of primary nasal cells exposed to disease-related modifiers, including IL-13, cigarette smoke condensate (CSC), and retinoic acid deficiency, all of which alter epithelial morphology. We also examined isolated tissue from inflamed nasal polyp and compared it with control middle turbinate. The data below reveal important alterations of the polarity of PAR-2 signaling in squamous cells and primary epithelial cells de-differentiated through disease-relevant mechanisms.
Search related documents:
Co phrase search for related documents- air liquid and chronic asthma: 1, 2
- air liquid and cigarette smoke: 1, 2, 3, 4, 5, 6
- air liquid and cystic fibrosis: 1, 2, 3, 4, 5
- air liquid and differentiate air liquid interface: 1, 2
- air liquid interface and CF cystic fibrosis: 1
- air liquid interface and chronic asthma: 1
- air liquid interface and cigarette smoke: 1, 2, 3, 4, 5, 6
- air liquid interface and cystic fibrosis: 1, 2, 3, 4, 5
- air liquid interface and differentiate air liquid interface: 1, 2
- airway signal and cigarette smoke: 1
- airway signal and cystic fibrosis: 1
- allergic disease and Aspergillus fumigatus: 1, 2
- allergic disease and bronchopulmonary aspergillosis: 1, 2, 3, 4, 5
- allergic disease and CF cystic fibrosis: 1
- allergic disease and chronic asthma: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- allergic disease and cigarette smoke: 1
- allergic disease and cystic fibrosis: 1, 2, 3
- Aspergillus fumigatus and bronchopulmonary aspergillosis: 1, 2, 3, 4
- Aspergillus fumigatus and cystic fibrosis: 1, 2, 3, 4
Co phrase search for related documents, hyperlinks ordered by date