Selected article for: "beta chain and binding affinity"
Author: A.J.W. Haasnoot; M.W. Schilham; S.S.M. Kamphuis; P.C.E. Hissink Muller; A. Heiligenhaus; D. Foell; R.A. Ophoff; T.R.D.J. Radstake; A.I. Den Hollander; T.H.C.M. Reinards; S. Hiddingh; N. Schalij-Delfos; E.P.A.H. Hoppenreijs; M.A.J. van Rossum; C. Wouters; R.K. Saurenmann; N. Wulffraat; R. ten Cate; J.H. de Boer; S.L. Pulit; J.J.W. Kuiper
Title: An amino acid motif in HLA-DRß1 distinguishes patients with uveitis in juvenile idiopathic arthritis
  • Document date: 2017_5_22
    • ID: 4it5c9n2_18
    Snippet: Polymorphisms in the beta chain specify the peptide binding preference of the HLA-DR molecule. Serine at position 11, as well as the adjacent associated amino acids at position 10 -13, are located in the bottom of the antigen-binding groove of the HLA-DRB1 protein (Figure 2) , suggesting that different peptide-binding preferences of HLA-DRB1 may confer risk for developing uveitis. To explore if the presence of serine at position 11 affects peptid.....
    Document: Polymorphisms in the beta chain specify the peptide binding preference of the HLA-DR molecule. Serine at position 11, as well as the adjacent associated amino acids at position 10 -13, are located in the bottom of the antigen-binding groove of the HLA-DRB1 protein (Figure 2) , suggesting that different peptide-binding preferences of HLA-DRB1 may confer risk for developing uveitis. To explore if the presence of serine at position 11 affects peptide-MHCII interactions, we compared the predicted binding affinity for 13 common HLA-DRB1 allotypes (representing 79% of DRB1 alleles in cases) using a large panel of >80,000 peptides based on human iris proteome data (Materials and Methods and Supplementary Table 4) using the NetMHCIIpan server. 38 Briefly, the neural networkbased NetMHCIIpan algorithm is capable of reliably detecting differences between peptidebinding repertoires of highly similar MHC class II molecules.

    Search related documents:
    Co phrase search for related documents
    • amino acid and beta chain: 1, 2, 3, 4, 5, 6, 7
    • amino acid and bind affinity: 1, 2, 3, 4, 5, 6, 7, 8
    • amino acid and class II molecule: 1, 2, 3, 4, 5
    • amino acid and DRB1 allele: 1
    • amino acid and large panel: 1, 2, 3, 4
    • amino acid and MHC class II molecule: 1
    • amino acid and netmhciipan server: 1
    • antigen bind and bind affinity: 1
    • class II molecule and HLA DR molecule: 1
    • class II molecule and MHC class II molecule: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
    • DRB1 allele and large panel: 1
    • HLA DR molecule and MHC class II molecule: 1