Selected article for: "amino acid and genome gene"
Author: A.J.W. Haasnoot; M.W. Schilham; S.S.M. Kamphuis; P.C.E. Hissink Muller; A. Heiligenhaus; D. Foell; R.A. Ophoff; T.R.D.J. Radstake; A.I. Den Hollander; T.H.C.M. Reinards; S. Hiddingh; N. Schalij-Delfos; E.P.A.H. Hoppenreijs; M.A.J. van Rossum; C. Wouters; R.K. Saurenmann; N. Wulffraat; R. ten Cate; J.H. de Boer; S.L. Pulit; J.J.W. Kuiper
Title: An amino acid motif in HLA-DRß1 distinguishes patients with uveitis in juvenile idiopathic arthritis
  • Document date: 2017_5_22
    • ID: 4it5c9n2_21
    Snippet: A number of HLA types and amino acid positions have been demonstrated to be associated to JIA, uveitis and related autoimmune diseases through genome-wide association and candidate gene studies. 20, 40, 41 We looked up 10 previously-associated HLA types and amino acids in our GWAS of (1) JIA and unaffected controls and (2) uveitis and unaffected controls. Seven of the 10 associations appeared in our data, and all associations were nominally signi.....
    Document: A number of HLA types and amino acid positions have been demonstrated to be associated to JIA, uveitis and related autoimmune diseases through genome-wide association and candidate gene studies. 20, 40, 41 We looked up 10 previously-associated HLA types and amino acids in our GWAS of (1) JIA and unaffected controls and (2) uveitis and unaffected controls. Seven of the 10 associations appeared in our data, and all associations were nominally significant (p < 0.05; Supplementary Table 6 and Supplementary Figure 8 ).

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