America Addresses Two Epidemics: Cannabis and Coronavirus and their Interactions: An Ecological Geospatial Study

Albert S Reece; Gary K Hulse

Supplementary Table 1 provides a tabulation of the states by their daily cannabis use quintile and the legal status of cannabis in 2020. Figure 3A shows a boxplot of the CVIR by quintile of daily cannabis use with Quintile 5 being the lowest daily use and Quintile 1 being the highest daily use. Whilst the trend appears to be positively skewed the notches of the boxes overlap indicating lack of statistical difference. Supplementary Table 2 shows the Prevalence ratio (PR, like odds ratio for cross-sectional data), the attributable fraction in the exposed (AFE) and the attributable fraction in the population (AFP) calculated numerically directly from the case numbers. As can be seen the PR's rise monotonically with Quintile number from 1.22 (95%C.I. 1.14-1.31) to 5.11 (4.90-5.33 comparison Χ 2 =567, df=2, P=7.54x10 -124 ). These data look different from those in Figure 3B due to the skewing effect of outliers. When non-parametric analysis was used on these CVIR the illegal-legal difference was significant (W=72, P=0.0239) but the illegaldecriminalized difference was not (W=180, P = 0.8965).