Author: Ping Liu; Jing-Zhe Jiang; Xiu-Feng Wan; Yan Hua; Xiaohu Wang; Fanghui Hou; Jing Chen; Jiejian Zou; Jinping Chen
Title: Are pangolins the intermediate host of the 2019 novel coronavirus (2019-nCoV) ? Document date: 2020_2_20
ID: 2inlyd0t_24
Snippet: The S protein of coronaviruses bind to host receptors via receptor-binding domains (RBDs), and plays an essential role in initiating virus infection and determines host tropism [2] . A prior study suggested that the 2019-nCoV, SARS-CoV, and Bat-CoV-RaTG13 had similar RBDs, suggested all of them use the same receptor ACE2 [9] . Our analyses showed that pangolin-CoV-2020 had a very conserved RBD to these three viruses rather than MERS-CoV, suggesti.....
Document: The S protein of coronaviruses bind to host receptors via receptor-binding domains (RBDs), and plays an essential role in initiating virus infection and determines host tropism [2] . A prior study suggested that the 2019-nCoV, SARS-CoV, and Bat-CoV-RaTG13 had similar RBDs, suggested all of them use the same receptor ACE2 [9] . Our analyses showed that pangolin-CoV-2020 had a very conserved RBD to these three viruses rather than MERS-CoV, suggesting that pangolin-CoV is very likely to use ACE2 as its receptor. On the other hand, ACE2 receptor is present in pangolins with a high sequence conservation with those in the gene homolog in humans. However, the zoonosis of this pangolin-CoV-2020 remains unclear.
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