Selected article for: "cc NC ND International license and negative regulation"
Author: Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Title: Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy
  • Document date: 2020_2_27
    • ID: egntml7e_100
    Snippet: . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.26.966143 doi: bioRxiv preprint Figure 8 FIGURE 8. Action mechanism flow chart of AS. AS interacted with VDR to prevent the nuclear translocation of VDR and decrease its negative regulation of autophagy related target genes such as ATG16L1, and then increa.....
    Document: . CC-BY-NC-ND 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.26.966143 doi: bioRxiv preprint Figure 8 FIGURE 8. Action mechanism flow chart of AS. AS interacted with VDR to prevent the nuclear translocation of VDR and decrease its negative regulation of autophagy related target genes such as ATG16L1, and then increase autophagy activity. Additionally, AS interacted with VDR to prevent the interaction between VDR and NF-κB p65, increase the nuclear translocation of NF-κB p65, then augment the transcription of its target genes such as pro-inflammatory cytokines.

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