Selected article for: "cytokine release and inflammation bacterial clearance"
Author: Shenglan Shang; Jiaqi Wu; Xiaoli Li; Xin Liu; Pan Li; Chunli Zheng; Yonghua Wang; Songqing Liu; Jiang Zheng; Hong Zhou
Title: Artesunate interacts with Vitamin D receptor to reverse mouse model of sepsis-induced immunosuppression via enhancing autophagy
  • Document date: 2020_2_27
    • ID: egntml7e_82
    Snippet: Herein, our results demonstrated that AS interacted with VDR to reverse sepsis-induced immunosuppression in an autophagy and NF-κB dependent way. Together with our previous results (Kuang et al., 2018; Li et al., 2008) , AS is discovered to not only inhibit pro-inflammatory cytokine release during hyper-inflammation stage but also enhance pro-inflammatory cytokines release and bacterial clearance by macrophages to reverse sepsis-induced immunosu.....
    Document: Herein, our results demonstrated that AS interacted with VDR to reverse sepsis-induced immunosuppression in an autophagy and NF-κB dependent way. Together with our previous results (Kuang et al., 2018; Li et al., 2008) , AS is discovered to not only inhibit pro-inflammatory cytokine release during hyper-inflammation stage but also enhance pro-inflammatory cytokines release and bacterial clearance by macrophages to reverse sepsis-induced immunosuppression in vivo and in vitro, demonstrating that AS exhibits an immunoregulating effect for sepsis treatment, which is not reported previously.

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