An exploratory randomized, controlled study on the efficacy and safety of lopinavir/ritonavir or arbidol treating adult patients hospitalized with mild/moderate COVID-19 (ELACOI)

Yueping Li; Zhiwei Xie; Weiyin Lin; Weiping Cai; Chunyan Wen; Yujuan Guan; Xiaoneng Mo; Jian Wang; Yaping Wang; Ping Peng; Xudan Chen; Wenxin Hong; Guangming Xiao; Jinxin Liu; Lieguang Zhang; Fengyu Hu; Feng Li; Feng Li; Fuchun Zhang; Xilong Deng; Linghua Li

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.19.20038984 doi: medRxiv preprint were excluded based on the following criteria: 1) known or suspected to be allergic to LPV/r or arbidol; 2) having severe nausea, vomiting, diarrhea or other complaints affecting oral intake or absorption in the digestive tract; 3) taking other drugs that may interact with LPV/r or arbidol; 4) having serious underlying diseases, including but not limited to heart, lung, or kidney disease, liver malfunction, or mental illnesses affecting treatment compliance; 5) complications with pancreatitis or hemophilia prior to the trial; 6) Pregnant or lactating women; 7) suspected or confirmed history of alcohol or substance use disorder; 8) participation in other drug trials within the past month; 9) deemed otherwise unsuitable for the study by researchers.