Author: Joshua A. Hayward; Mary Tachedjian; Adam Johnson; Tamsin B. Gordon; Jie Cui; Glenn A. Marsh; Michelle L. Baker; Lin-Fa Wang; Gilda Tachedjian
Title: Bats Possess Unique Variants of the Antiviral Restriction Factor Tetherin Document date: 2020_4_9
ID: eksi9yia_19
Snippet: Mapping the tetherin cDNA sequences against the P. alecto genome identified a single tetherin gene located on Scaffold KB030270 ( Figure 3A ), between the MVB12A (multivesicular body subunit 12A) and PLVAP (plasmalemma vesicle associated protein) genes, similar to the human tetherin gene (Viewable in the Ensembl genome browser: http://www.ensembl.org/Homo_sapiens/Location/View?db=core;g=ENSG00000130303; r=19:17402886-17405683). P. alecto Isoform .....
Document: Mapping the tetherin cDNA sequences against the P. alecto genome identified a single tetherin gene located on Scaffold KB030270 ( Figure 3A ), between the MVB12A (multivesicular body subunit 12A) and PLVAP (plasmalemma vesicle associated protein) genes, similar to the human tetherin gene (Viewable in the Ensembl genome browser: http://www.ensembl.org/Homo_sapiens/Location/View?db=core;g=ENSG00000130303; r=19:17402886-17405683). P. alecto Isoform B and C use an alternative splice acceptor site for the first intron, resulting in the 7 AA exclusion, while the distinct C-terminus of isoform C is a result of alternative mRNA splicing that incorporates exon 5 while excluding exon 4 used in isoform A and B ( Figure 3B ).
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